135 articles for thisTarget
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Discovery of core-structurally novel PTP1B inhibitors with specific selectivity containing oxindole-fused spirotetrahydrofurochroman by one-pot reaction.
East China Normal University
Furanoterpenes, new types of protein tyrosine phosphatase 1B inhibitors, from two Indonesian marine sponges, Ircinia and Spongia spp.
Tohoku Medical and Pharmaceutical University
An epigenetic modifier induces production of (10'S)-verruculide B, an inhibitor of protein tyrosine phosphatases by Phoma sp. nov. LG0217, a fungal endophyte of Parkinsonia microphylla.
University of Arizona
Discovery of novel, high potent, ABC type PTP1B inhibitors with TCPTP selectivity and cellular activity.
Qilu University of Technology
The design strategy of selective PTP1B inhibitors over TCPTP.
Chinese Academy of Sciences
In vitro and in silico PTP-1B inhibition and in vivo antidiabetic activity of semisynthetic moronic acid derivatives.
Universidad Aut£Noma Del Estado De Morelos
Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity.
Shanghai Institute of Materia Medica
Novel, potent, selective and cellular active ABC type PTP1B inhibitors containing (methanesulfonyl-phenyl-amino)-acetic acid methyl ester phosphotyrosine mimetic.
Qilu University of Technology
Synthesis of oleanolic acid derivatives: In vitro, in vivo and in silico studies for PTP-1B inhibition.
Universidad Aut£Noma Del Estado De Morelos
Discovery of novel, potent, selective and cellular active ADC type PTP1B inhibitors via fragment-docking-oriented de novel design.
Qilu University of Technology
Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.
Sanford-Burnham Medical Research Institute
A potent and selective inhibitor for the UBLCP1 proteasome phosphatase.
Indiana University
Design and synthesis of novel 1,2-dithiolan-4-yl benzoate derivatives as PTP1B inhibitors.
Chinese Academy of Sciences
Synthesis and biological evaluation of novel thiadiazole amides as potent Cdc25B and PTP1B inhibitors.
Liaoning Normal University
4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B.
Chinese Academy of Sciences
Synthesis and evaluation of several oleanolic acid glycoconjugates as protein tyrosine phosphatase 1B inhibitors.
North-West University
Synthesis, biological activity and structure-activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic effects in mouse C2C12 skeletal muscle cells.
University of Messina
Design, synthesis, and biological evaluation of novel 2-ethyl-5-phenylthiazole-4-carboxamide derivatives as protein tyrosine phosphatase 1B inhibitors with improved cellular efficacy.
Chinese Academy of Sciences
Substrate-based fragment identification for the development of selective, nonpeptidic inhibitors of striatal-enriched protein tyrosine phosphatase.
Yale University
Calix[4]arene methylenebisphosphonic acids as inhibitors of protein tyrosine phosphatase 1B.
National Academy of Sciences of Ukraine
Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11).
Case Western Reserve University
The first synthesis of natural disulfide bruguiesulfurol and biological evaluation of its derivatives as a novel scaffold for PTP1B inhibitors.
Chinese Academy of Sciences
A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases.
Indiana University School of Medicine
Design and synthesis of 2-substituted benzoxazoles as novel PTP1B inhibitors.
Aurigene Discovery Technologies
Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold.
Indiana University School of Medicine
Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors.
East China University of Science and Technology
Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.
East China Normal University
Design, synthesis, and evaluation of 2-substituted ethenesulfonic acid ester derivatives as protein tyrosine phosphatase 1B inhibitors.
Shanghai Jiao Tong University
Bromophenols as inhibitors of protein tyrosine phosphatase 1B with antidiabetic properties.
Chinese Academy of Sciences
Discovery of novel and potent heterocyclic carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors.
Advinus Therapeutics
New 4-[(5-arylidene-2-arylimino-4-oxo-3-thiazolidinyl)methyl]benzoic acids active as protein tyrosine phosphatase inhibitors endowed with insulinomimetic effect on mouse C2C12 skeletal muscle cells.
University of Messina
Novel thiophene derivatives as PTP1B inhibitors with selectivity and cellular activity.
Chinese Academy of Sciences
2-O-carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity.
Inha University
5-Arylidene-2,4-thiazolidinediones as inhibitors of protein tyrosine phosphatases.
Universit£
Methylenedisalicylic acid derivatives: new PTP1B inhibitors that confer resistance to diet-induced obesity.
Inha University
Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics.
University of Waterloo
Exploration ofa-aminophosphonate N-derivatives as novel, potent and selective inhibitors of protein tyrosine phosphatases.
Shanxi University
Discovery of potent, selective and orally bioavailable triaryl-sulfonamide based PTP1B inhibitors.
M.S. University of Baroda
Click to a focused library of benzyl 6-triazolo(hydroxy)benzoic glucosides: novel construction of PTP1B inhibitors on a sugar scaffold.
East China University of Science and Technology
Synthesis and biological evaluation of (±)-3-(2-(2-fluorobenzyloxy) naphthalen-6-yl)-2-aminopropanoic acid derivatives as novel PTP1B inhibitors.
Yanbian University
Novel thiazolidinedione derivatives with anti-obesity effects: dual action as PTP1B inhibitors and PPAR-¿ activators.
Inha University
Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening.
Indiana University
Facile fabrication of promising protein tyrosine phosphatase (PTP) inhibitor entities based on 'clicked' serine/threonine-monosaccharide hybrids.
East China University of Science and Technology
A unique and rapid approach toward the efficient development of novel protein tyrosine phosphatase (PTP) inhibitors based on 'clicked' pseudo-glycopeptides.
East China University of Science and Technology
Synthesis and evaluation of some novel dibenzo[b,d]furan carboxylic acids as potential anti-diabetic agents.
Glenmark Research Center
Bioactivity-guided isolation of 1,2,3,4,6-Penta-O-galloyl-D-glucopyranose from Paeonia lactiflora roots as a PTP1B inhibitor.
University of Vienna
Dammaranes from Gynostemma pentaphyllum and synthesis of their derivatives as inhibitors of protein tyrosine phosphatase 1B.
Chinese Academy of Sciences
Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B.
Chinese Academy of Sciences
Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.
University of California
Isolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060.
Silla University
Recent advances in the discovery of competitive protein tyrosine phosphatase 1B inhibitors for the treatment of diabetes, obesity, and cancer.
Incyte
Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.
East China Normal University
Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design.
University of Miami
Thiazolidinedione derivatives as PTP1B inhibitors with antihyperglycemic and antiobesity effects.
Inha University
Synthesis and evaluation of some novel isochroman carboxylic acid derivatives as potential anti-diabetic agents.
Glenmark Research Center
Derivatives of 1,4-bis(3-hydroxycarbonyl-4-hydroxyl)styrylbenzene as PTP1B inhibitors with hypoglycemic activity.
Inha University
Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities.
Chinese Academy of Sciences
Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action.
Chinese Academy of Sciences
Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.
Wyeth Research
Mono- and disalicylic acid derivatives: PTP1B inhibitors as potential anti-obesity drugs.
Inha University
Development of molecular probes for second-site screening and design of protein tyrosine phosphatase inhibitors.
Institute For Medical Research
Isosteviol derivatives as protein tyrosine Phosphatase-1B inhibitors: Synthesis, biological evaluation and molecular docking.
Shanghai Ocean University
Aldose reductase and protein tyrosine phosphatase 1B inhibitors as a promising therapeutic approach for diabetes mellitus.
Aristotle University of Thessaloniki
Current anti-diabetic agents and their molecular targets: A review.
University of Kwazulu-Natal
Selective Inhibition of PTP1B by New Anthraquinone Glycosides from
Binzhou Medical University
Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors.
Eli Lilly
Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta.
Procter & Gamble Pharmaceuticals
A gatekeeper residue for inhibitor sensitization of protein tyrosine phosphatases.
Amherst College
Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics.
Incyte
Pyrrospirones K-Q, Decahydrofluorene-Class Alkaloids from the Marine-Derived Fungus
Chinese Academy of Sciences
Chemistry, biosynthesis and biological activity of terpenoids and meroterpenoids in bacteria and fungi isolated from different marine habitats.
Iranian Fisheries Science Research Institute
Isoxazole derivatives as anticancer agent: A review on synthetic strategies, mechanism of action and SAR studies.
Central University of Punjab
Germacrane sesquiterpenes from leaves of Eupatorium chinense inhibit protein tyrosine phosphatase.
Tohoku Medical and Pharmaceutical University
The Inhibitors of Protein Tyrosine Phosphatase Nonreceptor Type 2 (PTPN2) as Potential Enhancers of Cancer Immunotherapy and Type 1 (PTPN1) as Treatment of Metabolic Diseases.
Therachem Research Medilab
Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors.
Merck Frosst Centre For Therapeutic Research
Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor.
Abbott Laboratories
Pyrrolo[1,2-a]quinoxal-5-inium salts and 4,5-dihydropyrrolo[1,2-a]quinoxalines: Synthesis, activity and computational docking for protein tyrosine phosphatase 1B.
Universidad De Alcal£
Formylchromone derivatives as a novel class of protein tyrosine phosphatase 1B inhibitors.
Inha University
Synthesis and biological evaluation of geniposide derivatives as potent and selective PTPlB inhibitors.
Shanghai Jiao Tong University
Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism.
Purdue University
Novel PTP1B inhibitors identified by DNA display of fragment pairs.
University of Geneva
Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.
Novo Nordisk
From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement.
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Synthesis and biological evaluation of heterocyclic bis-aryl amides as novel Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors.
Jiangnan University
Identification and characterization of potent and selective inhibitors targeting protein tyrosine phosphatase 1B (PTP1B).
Zhejiang Sci-Tech University
Calixarene-based phosphinic acids as inhibitors of protein tyrosine phosphatases.
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of The National Academy of Sciences of Ukraine
Investigation of stereoisomeric bisarylethenesulfonic acid esters for discovering potent and selective PTP1B inhibitors.
Shanghai Jiao Tong University (Sjtu)
Synthesis and PTP Inhibitory Activity of Illudalic Acid and Its Methyl Ether, with Insights into Selectivity for LAR PTP over Other Tyrosine Phosphatases under Physiologically Relevant Conditions.
University of Utah
Indole-Diterpenoids with Protein Tyrosine Phosphatase Inhibitory Activities from the Marine-Derived Fungus
Hebei University
Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors.
Chinese Academy of Sciences
Diketopiperazine-Type Alkaloids from a Deep-Sea-Derived Aspergillus puniceus Fungus and Their Effects on Liver X Receptor ?.
Chinese Academy of Sciences
Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections.
Indiana University School of Medicine
Benzofuran derivatives and their anti-tubercular, anti-bacterial activities.
Huanghuai University
Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus.
Helmholtz Zentrum M�Nchen
Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents.
Yanbian University College of Pharmacy
Discovery of 1,3-diphenyl-1H-pyrazole derivatives containing rhodanine-3-alkanoic acid groups as potential PTP1B inhibitors.
Yanbian University
Study of triaryl-based sulfamic acid derivatives as HPTP? inhibitors.
National Engineering Research Center For The Emergency Strategic Drug
Identification of caffeoylquinic acid derivatives as natural protein tyrosine phosphatase 1B inhibitors from Artemisia princeps.
China Pharmaceutical University
Benzo[c][1,2,5]thiadiazole derivatives: A new class of potent Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors.
Jiangnan University
Discovery of novel high potent and cellular active ADC type PTP1B inhibitors with selectivity over TC-PTP via modification interacting with C site.
Qilu University of Technology
Design, synthesis and biological evaluation of uncharged catechol derivatives as selective inhibitors of PTP1B.
Chinese Academy of Sciences
Varic acid analogues from fungus as PTP1B inhibitors: Biological evaluation and structure-activity relationships.
Dalian University of Technology
A bromopyrrole-containing diterpene alkaloid from the Okinawan marine sponge Agelas nakamurai activates the insulin pathway in Huh-7 human hepatoma cells by inhibiting protein tyrosine phosphatase 1B.
Tohoku Medical and Pharmaceutical University
Y-shaped bis-arylethenesulfonic acid esters: Potential potent and membrane permeable protein tyrosine phosphatase 1B inhibitors.
Shanghai Jiao Tong University
Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment.
Chinese Academy of Sciences
X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors.
Yale University
Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors.
Chinese Academy of Sciences
Synthesis and characterization of 5,7-dihydroxyflavanone derivatives as novel protein tyrosine phosphatase 1B inhibitors.
Yanbian University College of Pharmacy
Synthesis of (glycopyranosyl-triazolyl)-purines and their inhibitory activities against protein tyrosine phosphatase 1B (PTP1B).
East China University of Science and Technology
Synthesis and evaluation of oxovanadium(IV) complexes of Schiff-base condensates from 5-substituted-2-hydroxybenzaldehyde and 2-substituted-benzenamine as selective inhibitors of protein tyrosine phosphatase 1B.
Shanxi University
Design and synthesis of paracaseolide A analogues as selective protein tyrosine phosphatase 1B inhibitors.
Lanzhou University
Synthesis and biological evaluation of novel bis-aromatic amides as novel PTP1B inhibitors.
Jiangnan University
Preparation of triazole-linked glycosylated ??????-ketocarboxylic acid derivatives as new PTP1B inhibitors.
East China University of Science and Technology
Discovery of orally active, potent, and selective benzotriazole-based PTP1B inhibitors.
Zydus Research Centre
Design and synthesis of imidazolidine-2,4-dione derivatives as selective inhibitors by targeting protein tyrosine phosphatase-1B over T-cell protein tyrosine phosphatase.
Tianjin Medical University
Cellular inhibition of protein tyrosine phosphatase 1B by uncharged thioxothiazolidinone derivatives.
Mcgill University
Fragment-based substrate activity screening method for the identification of potent inhibitors of the Mycobacterium tuberculosis phosphatase PtpB.
University of California Berkeley
Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: capturing interactions with Asp48.
Wyeth Research
Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors.
Wyeth Research
Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors.
Abbott Laboratories
Identification of a monoacid-based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B.
Abbott Laboratories
Discovery and structure-activity relationship of oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B.
Abbott Laboratories
Discovery of a potent, selective protein tyrosine phosphatase 1B inhibitor using a linked-fragment strategy.
Abbott Laboratories
Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase.
Merck Frosst Center For Therapeutic Research